Table 1: Available therapies for EBV diseases.

Modalities Classification Comments Drug treatment Acyclovir/ganciclovir Inhibits virus replication and induces cell killing. Effective only against lytic EBV infection. Immunotherapy Vaccination Recombinant gp350-based vaccine, CTL epitope peptide-based vaccine. Treatment of disease Monoclonal antibody against CD21, anti CD-20 antibody (Rituximab); EBV-specific cytotoxic T cells from donor or ex vivo amplification of CTLs from patients and infusion back to the patient. Virus-directed approaches Utilization of presence of virus in the tumor Various cell-killing strategies that are dependent on EBV gene expression.