Table 1: Available therapies for EBV diseases.

ModalitiesClassificationComments

Drug treatmentAcyclovir/ganciclovirInhibits virus replication and induces cell killing. Effective only against lytic EBV infection.

ImmunotherapyVaccinationRecombinant gp350-based vaccine, CTL epitope peptide-based vaccine.
Treatment of disease Monoclonal antibody against CD21, anti CD-20 antibody (Rituximab); EBV-specific cytotoxic T cells from donor or ex vivo amplification of CTLs from patients and infusion back to the patient.

Virus-directed approachesUtilization of presence of virus in the tumorVarious cell-killing strategies that are dependent on EBV gene expression.