Table 2: Virus-directed novel approaches.

ClassesCommentsReference

Targeting EBV episomeLow dose hydroxyurea treatmentChodosh et al. [50], Slobod et al. [51]

Inhibition of EBV transforming proteinAntisense RNA against LMP-1 oncoproteinKenney et al. [52]
EBV-dependent expression of cellular toxinsExpression of detrimental cellular proteins through OriP dependent expression vectorHirai et al. [53], Kenney et al. [54]

Combination therapyInduction of EBV lytic replication + cytotoxic drugsNumerous, Listed in Table 3