Orthopoxvirus Genes That Mediate Disease Virulence and Host Tropism

Table 4

Orthopoxviral proteins modulating defense reactions of mammals.

Protein function	VACV-COP		CPXV-GRI		MPXV-ZAI		VARV-IND
	ORF	Size, aa	ORF	Size, aa	ORF	Size, aa	ORF	Size, aa
Apoptosis inhibitor, caspase-1 and caspase-8 inhibitor, SPI-2	B13R	116	B12R	345	B12R	344	B13R	344
Apoptosis inhibitor, SPI-1	C12L	353	B20R	375	B19R	357	B25R	372
Apoptosis inhibitor, Bcl-2-like	N1L	117	Q1L	117	P1L	117	P1L	117
Mitochondria-associated apoptosis inhibitor, caspase-9 inhibitor	F1L	226	G1L	238	C7L	219	C5L	251
Apoptosis inhibitor, transmembrane protein of Golgi apparatus	None	None	T1R	210	R1R	105	None	None
Apoptosis inhibitor, RING-domain containing E3 ubiquitin ligase	None	None	C7R	242	D5R	242	D4R	242
Apoptosis inhibitor, dsRNA-binding, interferon resistance	E3L	190	F3L	190	F3L	153	E3L	190
eIF-2α homolog, interferon resistance	K3L	88	M3L	88	None	None	C3L	88
Phosphatase, dephosphorylation of Stat 1	H1L	171	J1L	171	H1L	171	I1L	171
γ-IFN-binding	B8R	272	B7R	271	B9R	267	B9R	266
α/β-IFN-binding	B19R	353	B17R	351	B16R	352	B20R	354
IL-1β-binding	None	None	C8L	124	D6L	126	D5L	126
IL-18-binding	B16R	290	B14R	326	B14R	326	B15R	63
Complement binding	C3L	263	C17L	259	D14L	216	D12L	263
TNF- and chemokine-binding, CrmB	B28R	122	H4R	351	J2R	348	G2R	349
TNF-binding, CrmC	A53R	103	A56R	186	None	None	None	None
TNF- and chemokine-binding, CrmD	None	None	K2R	322	None	None	None	None
TNF-binding, CrmE	None	None	K3R	167	K1R	70	None	None
CC-chemokine-binding	B29R	244	I5R	255	J3R	246	G3R	253
CC- и CXC-chemokine-binding	A41L	219	A43L	219	A41L	221	A46L	218
Inhibitor of NK-mediated NKG2D-dependent lysis of infected cells	None	None	C2L	178	N3R	176	None	None
Inhibitor of MHC class II antigen presentation	A35R	176	A36R	176	A37R	176	A38R	60
Inhibitor of MHC class I complexes release from the PLC	None	None	D10L	96	None	None	None	None
Inhibitor of the intracellular trafficking of MHC class I molecules	B9R	77	B8R	221	B10R	221	None	None

ORFs that are altered/nonfunctional as compared with a CPXV-GRI counterpart are set in bold.