Table 4: Orthopoxviral proteins modulating defense reactions of mammals.

Protein functionVACV-COPCPXV-GRIMPXV-ZAIVARV-IND
ORFSize, aaORFSize, aaORFSize, aaORFSize, aa

Apoptosis inhibitor, caspase-1 and caspase-8 inhibitor, SPI-2B13R116B12R345B12R344B13R344
Apoptosis inhibitor, SPI-1C12L353B20R375B19R357B25R372
Apoptosis inhibitor, Bcl-2-likeN1L117Q1L117P1L117P1L117
Mitochondria-associated apoptosis inhibitor, caspase-9 inhibitorF1L226G1L238C7L219C5L251
Apoptosis inhibitor, transmembrane protein of Golgi apparatusNoneNoneT1R210R1R105NoneNone
Apoptosis inhibitor, RING-domain containing E3 ubiquitin ligaseNoneNoneC7R242D5R242D4R242
Apoptosis inhibitor, dsRNA-binding, interferon resistanceE3L190F3L190F3L153E3L190
eIF-2α homolog, interferon resistanceK3L88M3L88NoneNoneC3L88
Phosphatase, dephosphorylation of Stat 1H1L171J1L171H1L171I1L171
γ-IFN-bindingB8R272B7R271B9R267B9R266
α/β-IFN-bindingB19R353B17R351B16R352B20R354
IL-1β-bindingNoneNoneC8L124D6L126D5L126
IL-18-bindingB16R290B14R326B14R326B15R63
Complement bindingC3L263C17L259D14L216D12L263
TNF- and chemokine-binding, CrmBB28R122H4R351J2R348G2R349
TNF-binding, CrmCA53R103A56R186NoneNoneNoneNone
TNF- and chemokine-binding, CrmDNoneNoneK2R322NoneNoneNoneNone
TNF-binding, CrmENoneNoneK3R167K1R70NoneNone
CC-chemokine-bindingB29R244I5R255J3R246G3R253
CC- и CXC-chemokine-bindingA41L219A43L219A41L221A46L218
Inhibitor of NK-mediated NKG2D-dependent lysis of infected cellsNoneNoneC2L178N3R176NoneNone
Inhibitor of MHC class II antigen presentationA35R176A36R176A37R176A38R60
Inhibitor of MHC class I complexes release from the PLCNoneNoneD10L96NoneNoneNoneNone
Inhibitor of the intracellular trafficking of MHC class I moleculesB9R77B8R221B10R221NoneNone

ORFs that are altered/nonfunctional as compared with a CPXV-GRI counterpart are set in bold.