Research Article

In Silico and In Vitro Comparison of HIV-1 Subtypes B and CRF02_AG Integrases Susceptibility to Integrase Strand Transfer Inhibitors

Figure 1

Structural models of the HIV-1 INs from B and CRF02_AG strains. (a) Superimposition of models 1 and 2, representing the enzyme before the 3′ processing from B (in blue) and CRF02_AG (in yellow) strains; (b) Superimposition of models 3 and 4, representing the IN DNA pre-integration complex from B (in blue) and CRF02_AG (in yellow) strains; (c) and (d) Comparison of the catalytic site and loop 140–149 structure in models 1/3 (in blue) and 2/4 (in yellow) respectively. The proteins are shown as cartoons, Mg+2 ions as spheres (in pink). (e and f) superimposition of the structural subunits from models 1 (in blue) and 3 (in yellow) and the structural details of the active site and loop 140–149.
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