548657.fig.001a
(a)
548657.fig.001b
(b)
548657.fig.001c
(c)
548657.fig.001d
(d)
548657.fig.001e
(e)
548657.fig.001f
(f)
Figure 1: Structural models of the HIV-1 INs from B and CRF02_AG strains. (a) Superimposition of models 1 and 2, representing the enzyme before the 3′ processing from B (in blue) and CRF02_AG (in yellow) strains; (b) Superimposition of models 3 and 4, representing the IN DNA pre-integration complex from B (in blue) and CRF02_AG (in yellow) strains; (c) and (d) Comparison of the catalytic site and loop 140–149 structure in models 1/3 (in blue) and 2/4 (in yellow) respectively. The proteins are shown as cartoons, Mg+2 ions as spheres (in pink). (e and f) superimposition of the structural subunits from models 1 (in blue) and 3 (in yellow) and the structural details of the active site and loop 140–149.