Table 1: Amino acid variations at the positions putatively affecting the susceptibility to INSTI in 4 isolated HIV-1 subtype CRF02_AG IN coding sequences.

PositionB consensusSubtype CRF02_AG
N1 (33CR)N2 (49CR)N4 (52CR Q148K)N3 (68CR)

14KRKKR
112TVVRV
125TAAAA
134GNNGG
136KTTKT
206TSTSS
283SGGSS

Compared with HIV-1 subtype B IN, seven variations present at positions 14, 112, 125, 134, 136, 206, and 283 of CRF02_AG 33CR IN; five variations at positions 112, 125, 134, 136, and 283 of CRF02_AG 49CR IN; five variations at positions 14, 112, 125, 136, and 206 of CRF02_AG 68CR IN; CRF02_AG 52CR Q148K has two variations at positions 125 and 206, and an INSTI-resistant mutation Q148K, the R112 was not considered.