Research Article
In Silico and In Vitro Comparison of HIV-1 Subtypes B and CRF02_AG Integrases Susceptibility to Integrase Strand Transfer Inhibitors
Table 1
Amino acid variations at the positions putatively affecting the susceptibility to INSTI in 4 isolated HIV-1 subtype CRF02_AG IN coding sequences.
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Compared with HIV-1 subtype B IN, seven variations present at positions 14, 112, 125, 134, 136, 206, and 283 of CRF02_AG 33CR IN; five variations at positions 112, 125, 134, 136, and 283 of CRF02_AG 49CR IN; five variations at positions 14, 112, 125, 136, and 206 of CRF02_AG 68CR IN; CRF02_AG 52CR Q148K has two variations at positions 125 and 206, and an INSTI-resistant mutation Q148K, the R112 was not considered. |