Review Article
Retargeting of Viruses to Generate Oncolytic Agents
Table 1
Overview of the composition of bispecific adapters used to reroute viruses for oncolytic purposes.
| | Adaptor protein moiety binding to | Targeting demonstrated for | | Virion | Cell |
| | Antibody (scFv or Fab) | Antibody (scFv or Fab) | Adenovirus | | Adenoassociated virus | | Coronavirus | | Antibody (scFv or Fab) | Ligand peptide | Adenovirus | | Paramyxovirus |
| | Soluble/pseudo receptor | Antibody (scFv or Fab) | Adenovirus | | Herpesvirus | | Coronavirus | | Soluble/pseudo receptor | Ligand peptide | Adenovirus | | Coronavirus |
| | Polymer | Antibody (scFv or Fab) | Adenovirus | | Polymer | Ligand peptide | Adenovirus |
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