Review Article

Productive Entry Pathways of Human Rhinoviruses

Figure 1

Receptors for minor group viruses are expressed in nasal epithelial cells. Paraffin-embedded nasal tissue sections were prepared, rehydrated, and subsequently incubated with anti-LDLR [60] or anti-LRP1 [70] antibodies, followed by the respective fluorophore-labeled antichicken or antirabbit Alexa-488-IgG. Nuclei were stained with Hoechst dye. Pictures shown are overlays of immunofluorescence and phase contrast images. LDLR (a) and LRP1 (b) are present at the apical (yellow arrow heads) surface in ciliated as well as in basal cells (white arrow heads). A mucous secreting cell is indicated by a red arrow head.
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