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Advances in Virology
Volume 2013 (2013), Article ID 878237, 7 pages
http://dx.doi.org/10.1155/2013/878237
Research Article

Transmitted Drug Resistance among People Living with HIV/Aids at Major Cities of Sao Paulo State, Brazil

1Laboratório de Retrovírus, Centro de Virologia, Instituto Adolfo Lutz, Avenue Dr. Arnaldo 355, 01246-902 São Paulo, SP, Brazil
2Centro de Referência em DST/Aids, 13013-051 Campinas, SP, Brazil
3Centro de Referência e Treinamento em DST/Aids, 04121-000 São Paulo, SP, Brazil

Received 21 November 2012; Accepted 18 December 2012

Academic Editor: Michael Bukrinsky

Copyright © 2013 Joao Leandro Paula Ferreira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Human immunodeficiency virus type 1 (HIV-1) transmitted drug resistance (TDR) is an important public health issue. In Brazil, low to intermediate resistance levels have been described. We assessed 225 HIV-1 infected, antiretroviral naïve individuals, from HIV Reference Centers at two major metropolitan areas of Sao Paulo (Sao Paulo and Campinas), the state that concentrates most of the Brazilian Aids cases. TDR was analyzed by Stanford Calibrated Population Resistance criteria (CPR), and mutations were observed in 17 individuals (7.6%, 95% CI: 4.5%–11.9%). Seventy-six percent of genomes (13/17) with TDR carried a nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance mutation, mostly K103N/S (9/13, 69%), potentially compromising the preferential first-line therapy suggested by the Brazilian HIV Treatment Guideline that recommends efavirenz-based combinations. Moreover, 6/17 (35%) had multiple mutations associated with resistance to one or more classes. HIV-1 B was the prevalent subtype (80%); other subtypes include HIV-1 F and C, mosaics BC, BF, and single cases of subtype A1 and CRF02_AG. The HIV Reference Center of Campinas presented more cases with TDR, with a significant association of TDR with clade B infection ( ).