Mutations in the H, F, or M Proteins Can Facilitate Resistance of Measles Virus to Neutralizing Human Anti-MV Sera

Table 3

Fusion capacities of the six escape mutants selected for further study relative to Halle.

Virus	Mutations	% fusion
Halle (control)		100
Halle-SLAM 1.2	H.D332G; H.T380I; M.Y114H; M.I319T	84
Halle-SLAM 2.3	H.A158V; M.M239I	180
Halle-SLAM 5.1	F.I329N; M.T172I	69
Halle-CD46 1.2	F.M4I; F.V283A	75
Halle-CD46 1.3	H.T177I; H.R533G; M.I69T; M.I196V	66
Halle-CD46 3.3	H.L136P; M.K243E; M.S312P	95

To study fusion, cells (either CD46-expressing or SLAM-expressing according to the mutant tested) were infected by the different escape mutants and the percentage fusion quantified relative to (non-mutated) Halle (set at 100%).