Review Article
Adapted Lethality: What We Can Learn from Guinea Pig-Adapted Ebola Virus Infection Model
Table 3
Serum and peritoneal TNF activity in EBOV-infected guinea pigs and rabbits.
| | Virus | Guinea pigs | Rabbits | | Mayinga (wild-type) | 8mc, guinea pig-adapted | Mayinga (wild-type) |
| | TNF activity, serum (U/mL) | 3.4 ± 0.1 (day 7) | 2.5 ± 0.16 (day 7) | 104 ± 36 (day 3) | | 471 ± 137 (day 5) | | 1398 ± 909 (day 9) |
| | Virus titer, serum (PFU) | 103 | 104–105 | Nondetectable |
| | TNF activity, peritoneal (U/mL) | Nondetectable | Nondetectable | 15.3 ± 2.1 (days 5–9) |
| | Virus titer, peritoneal (PFU) | 102–103 | 102–103 | Nondetectable |
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