Research Article
Detection of HIV-1 and Human Proteins in Urinary Extracellular Vesicles from HIV+ Patients
Table 6
Functional enrichment analysis of HIV+ EV proteins.
| | Genes in the dataset | Genes in the Bkg. database | Percentage of genes | Fold enrichment | Corrected value (BH FDR) |
| Molecular function | | | | | | Protein serine/threonine kinase activity | 272 | 5,602 | 30 | 1.18 | 1.04−08 | Catalytic activity | 456 | 827 | 4.9 | 1.1 | 1.12−05 | GTPase activator activity | 131 | 836 | 4.7 | 1.2 | 8.14−05 | Guanyl-nucleoside exchange factor activity | 105 | 614 | 3.6 | 1.2 | 8.54−05 | Cell adhesion molecule activity | 307 | 531 | 3.3 | 1.1 | 0.0001 | Biological process | | | | | | Regulation of nucleobase, nucleoside, and nucleic acid | 2,236 | 4,658 | 24.8 | 1.05 | 3.24−05 | Biological pathway | | | | | | Integrin cell surface interactions | 69 | 1,366 | 23.3 | 1.2 | 0.03 |
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