Synthesis, Characterization, and In Vitro Cytotoxic Activities of Benzaldehyde Thiosemicarbazone Derivatives and Their Palladium(II) and Platinum(II) Complexes against Various Human Tumor Cell Lines

Table 1

Crystal data and refinement summary.

	HL^4	Pd(L^2)2⋅H2O	Pt4(L^4)4⋅2C2H5OH
Empirical formula	C14 H13 N3S	C18 H16 N8OPdS2	C60 H56 N12 O2Pt4 S4
Formula weight (g/mol)	255.33	530.91	1885.77
Crystal habit, color	Yellow plates	Orange prisms	Red prisms
Crystal system	Triclinic	Monoclinic	Monoclinic
Space group	P-1	C2/c	P21
a (Å)	5.988(1)	20.016(4)	12.708(1)
b (Å)	10.285(2)	6.421(1)	13.639(1)
c (Å)	11.410(2)	18.511(4)	17.031(1)
α (^°)	68.040(2)
β (^°)	82.514(3)	120.78(3)	94.054(1)
γ (^°)	86.886(2)
Volume (Å^3)	646.1(2)	2044.0(7)	2944.5(3)
Z; F(000)	2; 268	4; 1064	2; 1784
Densitycalc (g/cm^3)	1.313	1.725	2.127
Crystal size (mm)	0.44 × 0.20 × 0.04	0.43 × 0.39 × 0.07	0.16 × 0.16 × 0.05
μ(MoK𝛼)(mm^−1)	0.235	1.141	9.669
2θ range (^°)	3.8–50.0	6.8–56.2	3.8–59.0
Temperature (K)	220	213	213
Measured reflections	3388	9478	19123
𝑅int	0.0290	0.0635	0.0224
Unique reflections	2252	2462	13693
Observed reflections (𝐼>2𝜎(𝐼))	1939	2012	12253
Refined parameters	215	170	713
𝑤𝑅2 (unique reflections)	0.1693	0.0929	0.0774
𝑅1 (observed reflections)	0.0618	0.0331	0.0338
Largest difference peak and hole (e/ Å^3)	0.38/−0.31	1.26/−0.88	1.71/−1.14