Synthesis, Characterization, and In Vitro Cytotoxic Activities of Benzaldehyde Thiosemicarbazone Derivatives and Their Palladium(II) and Platinum(II) Complexes against Various Human Tumor Cell Lines

Table 4

IC₅₀(𝜇M) values of the palladium complexes, Pd(^1-3)₂, and the platinum tetranuclear complex, Pt₄ (L⁴)₄, against the different human tumor cell lines.

Human tumor cell lines	Pd(L^1)2	Pd(L^2)2	Pd(L^3)2	Pt4 (L^4)4
Lung large cell carcinoma (H460)	8.73	3.53	5.82	0.09
Cervix epidermoid carcinoma (ME180)	10.47	3.67	8.06	0.12
Prostate carcinoma (DU145)	11.59	1.99	9.30	0.10
Breast adenocarcinoma (MCF-7)	8.18	2.09	6.14	0.08
Amelanotic melanoma (M-14)	12.46	1.87	8.74	0.11
Colon adenocarcinoma (HT-29)	7.45	1.35	5.96	0.07
Prostate carcinoma (PC-3)	10.20	1.56	7.36	0.08
Chronic myelogenous leukemia (K562)	6.15	0.45	3.04	0.08

^(a)Cl₅₀ corresponds to the concentration required to inhibit a 50% of the cell growth when the cells are exposed to the compounds during 48 hours. Each value is the average of two independent experiments.