]>Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids : Table 4
Table 4: I C 5 0 values for LOX inhibition activity and cell cytotoxic activity of organotin(IV) complexes 1–6.
Compound I C 5 0 for LOX inhibition I C 5 0 cell activity Ref
[ ( C H 3 ) 2 Sn ( 𝑜 - H B Z A ) 2 ] (1)76  𝜇 m > 2000 nm [ ∗ ]
[ ( 𝑛 - C 4 H 9 ) 2 Sn ( 𝑜 - H B Z A ) 2 ] (2)48  𝜇 m150 nm [ ∗ ]
[ ( 𝑛 - C 4 H 9 ) 3 Sn ( 𝑜 - H B Z A ) ] (3)82  𝜇 m150 nm [ ∗ ]
[ ( C 6 H 5 ) 3 Sn ( 𝑜 - H B Z A ) ] (4)19  𝜇 m5-10 nm [ ∗ ]
[ ( 𝑛 - C 4 H 9 ) 3 Sn ( 𝑝 - H B Z A ) ] (5)24  𝜇 m30-40 nm [ ∗ ]
[ ( C 6 H 5 ) 3 Sn ( 𝑝 - H B Z A ) ] (6)11  𝜇 m25-35 nm [ ∗ ]
( 𝑛 - B u ) 3 Sn ( T B A ) ⋅ H 2 O ] 25  𝜇 m125 nM[14]
[ ( C 6 H 5 ) 3 Sn(MNA)Sn ( C 6 H 5 ) 3 (acetone)]14  𝜇 m5 nm[14]
[ ( C 6 H 5 ) 3 Sn(MBZT)]19  𝜇 m1500–3000 nm[15]
[ ( C 6 H 5 ) 3 Sn(MBZO)]16  𝜇 m1300–3000 nm[15]
[ ( C 6 H 5 ) 3 Sn(CMBZT)]21  𝜇 m500–800 nM[15]
[ ( C 6 H 5 ) 2 Sn ( C M B Z T ) 2 ] 10  𝜇 m300–500 nm[15]
[ ( 𝑛 - C 4 H 9 ) 2 Sn ( C M B Z T ) 2 ] 13  𝜇 m600–800 nm[15]
[ ( C H 3 ) 2 Sn ( C M B Z T ) 2 ] 14  𝜇 m5000–7500 nm[15]
[ ( C H 3 ) 2 Sn ( P M T ) 2 ] 61  𝜇 m20000–60000 nm[16]
[ ( 𝑛 - C 4 H 9 ) 2 Sn ( P M T ) 2 ] 26  𝜇 m700 nm[16]
[ ( C 6 H 5 ) 2 Sn ( P M T ) 2 ] 21  𝜇 m1000–2000 nm[16]
[ ( C 6 H 5 ) 3 Sn(PMT)]17  𝜇 m100 nm[16]
[ ∗ ] : This work; HTBA: 2-thiobarbituric acid; H 2 MNA: 2-mercapto-nicotinic acid; MBZT: 2-mercapto-benzothiazole; MBZO: 2-mercapto-benzoxazole; CMBZT: 5-chloro-2-mercapto-benzothiazole; HPMT: 2-mercapto-pyrimidine.