Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msub><mml:mtext>VO</mml:mtext><mml:mtext>2</mml:mtext></mml:msub></mml:math>(mpETSC)] and [Pt(mpETSC)Cl]

<table class="table-group" id="tab9"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td align="left">Compound</td><td align="center">HmpETSC</td><td align="center">[Zn(HmpETSC)Cl<sub>2</sub>]</td><td align="center">[Pd(mpETSC)Cl]</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td align="left">IC<sub>50</sub>, <math id="M198" xmlns="http://www.w3.org/1998/Math/MathML"><mrow><mi>μ</mi></mrow></math>M</td><td align="center">14.59</td><td align="center">16.96</td><td align="center">20.65</td></tr><tr><td align="left">SD</td><td align="center">0.81</td><td align="center">0.46</td><td align="center">1.60</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Antineoplastic activity in human colon tumor cell lines (HCT116) by growth inhibition SRB assay after 96-hour  treatment.

Bioinorganic Chemistry and Applications

tab9

Table 9

Table 9: Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msub><mml:mtext>VO</mml:mtext><mml:mtext>2</mml:mtext></mml:msub></mml:math>(mpETSC)] and [Pt(mpETSC)Cl] 

Table 9 | Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl] 