Synthesis and Biological Evaluation of New CRH Analogues

Table 1

Structure of synthesized CRH analogues.

	Human/Rat CRH	Analogue 1	Analogue 2	Analogue 3	Analogue 4	Analogue 5	Analogue 6	Analogue 7
1	S
2	E
3	E
4	P
5	P
6	I
7	S
8	L
9	D
10	L
11	T
12	E	D-phe	D-phe	D-phe	D-phe	D-phe	D-phe	D-phe
13	H
14	L	Aib
15	L		Aib
16	R
17	E
18	V
19	L
20	E
21	M			Cys(Et)		Cys(Et)	Cys(Pr)	Cys(Pr)
22	A
23	R
24	A
25	E
26	Q
27	L
28	A
29	Q
30	Q
31	A
32	H
33	S
34	N
35	R
36	K
37	L
38	M				Cys(Pr)	Cys(Pr)	Cys(Et)	Cys(Pr)
39	E
40	I
41	I