Synthesis and Biological Evaluation of New CRH Analogues

Table 4

Biological activity of h/r-CRH analogues.

	Analogues	Biological activity
	h/r-CRH	100% activity (Full agonist)
1	[D-Phe^12, Aib^14]CRH	(Partial Agonist, 60% Response max/CRH)
2	[D-Phe^12, Aib^15]CRH	(Partial Agonist, 60% Response max/CRH)
3	[D-Phe^12, Cys(Et)^21]CRH	(Full Agonist, 110% Response max/CRH)
4	[D-Phe^12, Cys(Pr)^38]CRH	(Partial Agonist, 60% Response max/CRH)
5	[D-Phe^12,Cys(Et)^21, Cys(Pr)^38]CRH	(Partial Agonist, 70% Response max/CRH)
6	[D-Phe^12, Cys(Pr)^21, Cys(Et)^38]CRH	(Partial Agonist, 60% Response max/CRH)
7	[D-Phe^12, Cys(Pr)^21, Cys(Pr)^38]CRH	(Partial Agonist, 80% Response max/CRH)