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Bioinorganic Chemistry and Applications
Volume 2010 (2010), Article ID 861892, 9 pages
http://dx.doi.org/10.1155/2010/861892
Research Article

The Catalytic Function of Nonheme Iron (III) Complex for Hydrocarbon Oxidation

Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece

Received 13 March 2010; Accepted 10 May 2010

Academic Editor: Spyros Perlepes

Copyright © 2010 Giorgos Bilis and Maria Louloudi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A detailed catalytic study of (where - -[2-(3-hydroxy-1,3-diphenyl-allylideneamino)-ethylamino]- -1,3-diphenyl-propen-1-ol) for hydrocarbon oxidation was carried out, focusing on the role of solvent, atmospheric dioxygen, and oxidant on catalytic efficiency. The data showed that catalyst was efficient in homogeneous hydrocarbon oxidations providing significant yields. Moreover, tert-BuOOH provided comparable oxidation yields with , slightly favoring the formation of alcohols and ketones versus epoxides. Dioxygen intervened in the catalytic reaction, influencing the nature of oxidation products. The polarity of solvent strongly influenced the reaction rates and the nature of oxidation products. A mechanistic model is postulated assuming that functions via the formation of iron-hydroperoxo-species, followed by a radical-based mechanistic path.

1. Introduction

Hydrocarbon oxidation, under mild and environmental friendly conditions, is an important research field, since industrial processes, especially in pharmaceutical industry, are based on the efficiency of direct and selective transformation of hydrocarbons in oxygen-containing products such as aldehydes, ketones alcohols, diols, and epoxides [1, 2]. However, selective oxidation of alkanes, under mild conditions, is a difficult task due to their chemical inertness. Nevertheless, in nature many iron enzymes activate dioxygen and catalyze the stereospesific oxidation of C=C or C–H bonds [3, 4]. Heme iron-proteins such as hemoglobin, myoglobin and cytochromes oxygenase [5] and nonheme enzymes such as methane monooxygenase [6, 7] and Rieske dioxygenases [8, 9] are able to oxidize hydrocarbons [10] via biochemical oxygen transport and electron-transfer reactions.

The objective to construct convenient artificial systems for efficient hydrocarbon oxidation using biomimetic iron complexes [11, 12] as catalysts [1315] by activating green oxidants is particularly interesting. Bioinspired catalytic systems commonly use mild oxidants such as dioxygen, hydrogen peroxide, or tert-butyl hydrogen peroxide (TBHP) [1620]. In this context, stereoselective hydroxylation, epoxidation, and cis-dihydroxylation by synthetic iron-biomimetic catalysts have been reported [2129]. Iron-peroxo species are invoked to be part of the mechanism of several bioinspired oxidation catalysts [30, 31]. More particularly, iron-complexes react with H2O2 or alkyl hydroperoxides forming low-spin OOH [32, 33] or OOR [34, 35] which are the key-species in oxidation reactions [16].

Recently, we have reported the synthesis and characterization of the ligand 3- 2-[2-(3-hydroxy-1,3-diphenyl-allylideneamino)-ethylamino]-ethylimino -1,3-diphenyl-propen-1-ol and its immobilization on silica surface via formation of covalent bridging between the ligand secondary amine and the silica OH-groups [36, 37]. Herein for brevity this ligand will be named L. The corresponding Mn(II) [36, 37] and Fe(III) [38] catalysts were shown to have remarkable catalytic activity in hydrocarbons oxidation using H2O2 as oxidant.

In the present contribution, we report a detailed catalytic study of L Cl focusing mainly on the influence of (a) atmospheric dioxygen, (b) solvent system, and (c) oxidant on its catalytic efficiency. The obtained information is compared with previous data of the L Cl catalyst, and mechanistic aspects are also discussed.

2. Experimental

2.1. General

All substrates were purchased from Aldrich, in their highest commercial purity, stored at C and purified by passage through a column of basic alumina prior to use. Hydrogen peroxide was 30% aqueous solution and tert-BuOOH was 5 M solution in decane.

Infrared spectra were recorded on a Spectrum GX Perkin-Elmer FT-IR System. UV-Vis spectra were recorded using a UV/VIS/NIR JASCO Spectrophotometer. The iron amount was determined by Flame Atomic Absorption spectroscopy on a Perkin-Elmer AAS-700 spectrometer. Mössbauer spectra were recorded with a constant acceleration spectrometer using a 57Co (Rh) source at room temperature and a variable-temperature. X-band Electron Paramagnetic Resonance (EPR) spectra were recorded using a Brucker ER200D spectrometer at liquid N2 temperatures, equipped with an Agilent 5310A frequency counter. The spectrometer was running under a home-made software based on LabView described earlier [39]. Mass spectra were measured on a Agilent 1100 Series LC-MSD-Trap-SL spectrometer and solution. Thermogravimetric analyses were carried out using Shimadzu DTG-60 analyser. GC analysis was performed using an 8000 Fisons chromatograph with a flame ionization detector and a Shimadzu GC-17A gas chromatograph coupled with a GCMS-QP5000 mass spectrometer.

2.2. Catalysts Preparation and Characterization
2.2.1. Preparation of Cl

To a stirred solution of ethanol and acetonitrile (15 ml) containing the ligand L=  3- 2-[2-(3-hydroxy-1,3-diphenyl-allylideneamino)-ethylamino]-ethylimino -1,3-diphenyl-propen-1-ol [36, 37] a solution of FeCl3 in a mixture of EtOH and CH3CN was added slowly. The resulting mixture was stirred for 24 h at room temperature. Partially solvent evaporation resulted in separation of an orange solid product. The obtained L Cl complex was washed with EtOH and CH3CN and dried under reduced pressure.

2.2.2. Characterization of Cl

Iron analysis by Flame Atomic Absorbance Spectroscopy and ESI-MS analysis indicated a molecular peak at m/z 605.2 that is attributed in formation. The IR bands at 3297, 1591, and 1523 cm-1 were attributed to the (NH), (C=N), and (NH) vibrations. In the spectrum of the metal-free ligand L, the corresponding vibrations were detected at 3350, 1600, and 1535 cm-1; this shift indicates metal coordination to imine- and amine-nitrogen. In the IR spectra of L and the L Cl the (C–O) vibration was appeared at 1398 and 1389 cm-1, respectively, suggesting strong coordination of Fe to the enolic oxygen atoms of the ligand L. Information about the iron center was obtained by Electron Paramagnetic Resonance (EPR) and Mössbauer spectroscopy. At 78 K, the Mössbauer parameters are and indicating an octahedral high-spin ( ) center, with the iron bound to nitrogen and oxygen atom donors [40]. The EPR spectrum of solid L Cl is characerised by two peaks at and 9.2, characteristic of a high-spin ) center in a rhombic ligand-field characterized by [41]. The UV-Vis spectrum of L Cl in CH3CN contains absorption bands at 282 ( ) and 314 nm ( ) due to intraligand transitions in the imine- and phenyl-groups [42]. The absorptions at 413 nm ( ) and 512 nm ( ) are attributed to LMCT [43]. The low-intensity 512 nm absorption can be attributed to charge transfer from ligand oxygen atoms to metal centre ( ). Usually, a ( ) transition is also observed at higher energy than the transition and could be related to the transition at 413 nm [35, 36]. The presence of -Cl bond also allows the presence of LMCT involving chloride orbitals [43, 44].

2.3. Catalytic Evaluation
2.3.1. GC-MS

H2O2 or tert-BuOOH diluted in solvent (CH3CN or tert-amylalcohol) was slowly added (within a period of 5 min) to a solvent solution containing the catalyst and the substrate, at room temperature ( C). For brevity in the text [H2O2 in tert-amylalcohol] will be referred as system A, [H2O2 in CH3CN] as system B, and [tert-BuOOH in CH3CN] as system C, respectively. As an internal standard, acetophenone or bromobenzene were used. Catalytic reactions were initiated by adding the oxidant into reaction mixture.

The progress of the reaction was monitored by GC-MS, by removing small samples of the reaction mixture. The yields reported herein are based on the amount of oxidant H2O2 converted to oxygenated products. To establish the identity of the products unequivocally, the retention times and spectral data were compared to those of commercially available compounds. Blank experiments showed that, without catalyst, no oxidative reactions take place.

2.3.2. Reaction Conditions

(1) Optimization of [Oxidant : Substrate] Ratio
To explore the optimum [oxidant-substrate] molar ratio, a first set of catalytic experiments was performed where the amount of substrate was kept constant and the amount of H2O2 was varied. Subsequently, a second set of catalytic experiments was run for varied amounts of substrate, using the optimum amount of H2O2 found in the first screening. For this screening, cyclooctene (Figure 1(a)), cyclohexene (Figure 1(b)), styrene (Figure 1(c)), and cyclohexane (Figure 1(d)) were tested. It is noted that H2O2 was diluted in acetonitrile (1/10 v/v) prior use, and it was introduced into the reaction mixture slowly.
Based on the data of Figures 1(a)1(d), the higher oxidation yield was obtained by small amounts of H2O2 and large excess of substrate. This is consistent with the current view that (a) high oxidant concentration causes oxidative destruction of catalyst, (b) large excess of substrate protects the catalyst from oxidative degradation, and, moreover, (c) this substrate large excess minimizes the overoxidation of initial oxidation products [45].
Based on analogous experiments for all the substrates used in the present study, we found that for cyclohexene, methyl-cyclohexene, cyclooctene, limonene, and cyclohexane oxidation, the optimum molar ratio of [catalyst : oxidant : substrate] was equal to [1 : 20 : 1000] and for styrene, trans- -methyl styrene and cis-stilbene oxidation, this molar ratio was equal to [1 : 50 : 1000].

fig1
Figure 1: (a) Cis-cyclooctene oxidation is catalysed by L Cl at varied Substrate-Oxidant molar ratio in CH3CN with H2O2. (b) Cyclohexene oxidation is catalysed by L Cl at varied Substrate-Oxidant molar ratio in CH3CN with H2O2. (c) Styrene oxidation is catalysed by L Cl at varied Substrate-Oxidant molar ratio in CH3CN with H2O2. (d) Cyclohexane oxidation is catalysed by L Cl at varied Substrate-Oxidant molar ratio in CH3CN with H2O2. For all figures The given ratio is catalyst : oxidant : substrate.

(2) Excess of Dioxygen
Iron-based catalysts, in the presence of dioxygen, often adopt radical mechanistic paths. Thus, the L Cl catalyst was evaluated in oxidation reactions with H2O2, (a) under atmospheric air versus (b) under inert Ar atmosphere (Table 1, Figure 2).
Based on the data of Table 1, it is observed that (a) the total yield of some oxidation reactions under air was over 100%; moreover, (b) the total oxidation yield under Ar was decreased. Especially, alcohol and ketone yields were strongly decreased under Ar. This suggests O2-involvement in the oxidation process which possibly propagates a radical autooxidation [46, 47] of the more reactive oxygen-containing products such as alcohols and ketones. Thus, to record reliable data, all catalytic experiments herein were performed under a vigorous Ar purge to avoid any trace of O2.

tab1
Table 1: Hydrocarbon oxidations catalyzed by LFeCl with H2O2 in CH3CN under atmospheric air and under Ar.
861892.fig.002
Figure 2: Bar chart representation of oxidations catalyzed by L Cl with H2O2 in CH3CN under atmospheric air and under Ar.

(3) Solvent Effect on the Reaction Time
The time course profiles of the L Cl-catalysed oxidation of cyclohexene with H2O2 in CH3CN and in tert-amylalcohol are given in Figure 3. According to these data the catalytic reaction was practically accomplished within 4 h in CH3CN and within 12 h in tert-amylalcohol. Thus, the reaction rate is strongly influenced by solvent. This effect could be related to the solvent polarity. However, in both solvents, the total yield of cyclohexene oxidation is quite high providing 88.5% in CH3CN and 79.0% in tert-amylalcohol. It is noted that cyclohexene oxidation, in CH3CN with tert-BuOOH as oxidant, was complete within 2 h, resulting in a 76.3% total yield.

861892.fig.003
Figure 3: Time-dependent reaction profiles for cyclohexene oxidation catalysed by L Cl with H2O2 in CH3CN and tert-amylalcohol.

3. Results and Discussion

3.1. Hydrocarbon Oxidation by the -Catalysts

The catalytic activity of L Cl for hydrocarbon oxidation was evaluated using tert-BuOOH and H2O2  as oxidants in either CH3CN or tert-amylalcohol. Cyclohexene, methyl-cyclohexene, cyclooctene, limonene, and cyclohexane were used as substrates with a ratio of catalyst : oxidant : substrate equal to 1 : 20 : 1000 and styrene, trans- -methyl styrene and cis-stilbene with a ratio of catalyst : oxidant : substrate equal to 1 : 50 : 1000. All oxidation reactions were carried out at room temperature under Ar atmosphere as described in details in Experimental Section. The obtained catalytic results are summarized in Table 2. Figure 4 provides a histogram-plot of the data of Table 2. The catalytic data of L Cl with H2O2  in CH3CN were taken from [38] and are included here for comparison.

tab2
Table 2: Hydrocarbon oxidation by L Cl catalyst.
861892.fig.004
Figure 4: Distribution of oxidation products catalyzed by L Cl, (a) in tert-amylalcohol with H2O2, (b) in CH3CN with H2O2, and (c) in CH3CN with tert-BuOOH. See Table 2 for further details.

Based on Table 2 we observe that cyclohexene and limonene oxidation catalyzed by the LFeCl provided oxidation products with a combined yield of 79.0% and 93.7%, respectively, in tert-amylalcohol with H2O2 (system A), 88.5% and 99.8% in CH3CN with H2O2   (system B), and 76.3% and 82.34% in CH3CN with tert-BuOOH (system C). Cyclohexene undergoes mainly allylic oxidation forming 2-cyclohexene-1-ol and 2-cyclohexene-1-one (with yields 16.0% and 50.7%, resp., by system A, 52.0% and 30.0% by system B, and 37.0% and 37.0% by system C). However cyclohexene epoxidation is also observed, providing low epoxide yields 12.3%, 6.5%, and 2.3% by systems A, B, and C, respectively. It is note that in tert-amylalcohol, the yield of epoxide and ketone increases, while the alcohol yield is reduced.

The major products detected from limonene oxidation were (i) two epoxides (cis- and trans-) derived from epoxidation of the electron-rich double bond at 1,2- position and (ii) alcohols derived from hydroxylation of the double bond at 1- and 2-position and from hydroxylation at 6-position closed to 1,2-double bond. Oxidation products from the more accessible, though less electron-rich, double bond at 8,9-position were not observed. Additionally, considerable amounts of the corresponding ketone at 6-position were also formed. In summary, the yield (a) of limonene-epoxides (cis-1,2 and trans-1,2) was found to be 51.2% in system A, 33.3% in system B, and 27.4% in system C, (b) of limonene-alcohols (1-ol, 2-ol, and 6-ol) 33.5%, 54.0%, and 46.9%, respectively and (c) of 6-ketone 9.0%, 12.5%, and 8% in systems A, B, and C respectively. These data provide a total catalytic oxidation of limonene 93.7%, 99.8%, and 82.3% achieved by LFeCl, respectively, in tert-amylalcohol with H2O2 (system A), in CH3CN with H2O2 (system B), and in CH3CN with tert-BuOOH (system C).

When methyl-cyclohexene was used as substrate, the detected oxidation products were cis-epoxide, 1-methyl-2-cyclohexen-1-ol, 3-methyl-2-cyclohexen-1-ol, and 3-methyl-2-cyclohexen-1-one. The corresponding yields found to be [40.0%, 20.0%, and 29.0%], [21.3%, 25.6%, and 23.7%], [24.5% 42.0%, and 36.3%], and [10.9%, 8.8%, and 8.5%] in catalytic systems A, B, and C, respectively. Generally, methyl-substituted alkenes are more reactive towards both epoxidation and allylic oxidation. Our findings confirm this aspect providing total yield of methyl-cyclohexene oxidation 93.7%, 98.8%, and 83.3% by the present catalytic systems.

Cis-cyclooctene as substrate afforded a single-product reaction with H2O2 catalysed by L Cl resulting only in cis-cyclooctene epoxide with 53.0% and 37.0% yields in systems A and B, respectively. However, the use of tert-BuOOH as oxidant provided 28% epoxide and 10% 2-cyclooctenone. Generally, cyclooctene occurs more readily epoxydation than allylic oxidation; however, here with tert-BuOOH, overoxidized 2-cyclooctenone derived from allylic oxidation was also detected.

Cis-stilbene oxidation in catalytic systems A and C provided cis- and trans- epoxides as major products [9.5% and 30% in system A] and [2.4% and 23.0% in C]. Benzaldehyde as oxidative cleavage product was also formed with yields 14% and 20%, respectively. In Catalytic system B, the detected products were benzaldehyde with yield 36.0% and cis-stilbene epoxide with yields 15.8%.

Styrene oxidation provided benzaldehyde as major product derived by oxidative cleavage of the exo-cyclic double bond with yields 20.0%, 35.0%, and 45.0% in systems A, B, and C, respectively. However, epoxide and phenyl acetaldehyde have been also formed by direct oxidation of the same double bond with [25.0% and 1.6%] in system A, [7.5% and 7.0%] in system B, and [3.0% and 1.6%] in system C. Overall, styrene was oxidised by L Cl in different oxidation conditions providing total yields from 46.6% to 49.6%.

The methyl-substituted styrene, trans- -methyl styrene, is more reactive than styrene showing total oxidation yields 97.2%, 93.2%, and 65.8% in catalytic systems A, B, and C, respectively. The identified products were trans-epoxide (47.7%, 41.9%, and 42.0%) and benzaldehyde as oxidation cleavage adduct (45.0%, 40.0%, and 15.8%). In some cases, methyl-benzyl-ketone and methyl-benzyl-alcohol were also detected.

Finally, cyclohexane oxidation by the present -catalyst, in the three A, B, and C catalytic conditions, gave cyclohexanol and cyclohexanone with combined yields 8.0%, 12.2%, and 7.0% while the corresponding alcohol/ketone (A/K) ratio was found to be 1.66, 1.75, and 1.71, respectively.

3.2. Mechanistic Considerations

The A/K ratio in cyclohexane can be used as a criterion of the presence and lifetime of free alkyl radical intermediates [31] as follows: (i) when , then we assume that the alkyl radicals are long-lived with a strong tendency to interact with O2 to form alkyl-peroxy-radicals [45]. At the end, following a Russell-type terminal stage [48], recombination of these radicals results in the formation of equimolar amounts of alcohol and ketone [21, 31]. (ii) When , the radical OH is formed by a metal-based system and the metal center reacts directly to form the corresponding alcohol. This is consistent with the formation of –OOH intermediate and the homolytic cleavage of O–O bond to HO radical and oxoiron(IV) followed by electrophilic addition of metal-based species to the substrate.

Hydrocarbon oxidations catalyzed by L Cl presented comparable selectivity and distribution of oxidation products, in the three experimental conditions studied herein. This implies similar mechanistic path in the catalysis. Generally, L Cl is able to generate iron-hydroperoxo-species under the mild oxidation conditions used. It is known from other nonheme iron systems that –OOH could be either (a) a precursor or (b) itself an oxidant [22, 28, 46]. In the first case, possible homolytic cleavage of O–O bond leads to an =O species and reactive HO radical while a heterolytic cleavage generates an =O and an species [22, 28, 46]. Herein, the major oxidation products of alkenes are alcohols and ketones, mainly derived by an allylic oxidation reaction. However, considerable amounts of epoxides have been also formed. Taking into account that the detected allylic oxidation products are the main component of the observed oxidation yield, a dominant radical mechanistic path is suggested. This suggestion is further supported by detection of traces of the compounds illustrated in Scheme 2. Their formation could be a result of (a) interaction between two allyl-radicals formed on substrates and (b) interaction of an allyl-radical on substrate and a hydro-peroxo radical.

861892.sch.001
Scheme 1: Schematic representation of ligand [3- 2-[2-(3-hydroxy-1,3-diphenyl-allylideneamino)-ethylamino]-ethylimino -1,3-diphenyl-propen-1-ol] (L).
861892.sch.002
Scheme 2: Schematic representation of detected byproducts.

In this context, when tert-amylalcohol—a less polar solvent—was used with H2O2, the reaction time is considerably longer, the yield of the corresponding epoxides increased, and the yield of radical mechanism products, that is, alcohols and ketones decreases. On the other hand, the use of tert-BuOOH as oxidant enhanced the yield of the corresponding alcohols and ketones.

4. Conclusion

The L Cl catalyst was efficient in homogeneous hydrocarbon oxidations providing significant yields. The catalytic experiments (a) were performed under inert argon atmosphere excluding any trace of O2 which favors radical oxidation paths and (b) included large excess of substrate, protecting the catalyst from oxidative degradation and minimizing the overoxidation of initial oxidation products. tert-BuOOH provided comparable oxidation yields with H2O2; nevertheless it slightly favors the formation of alcohols and ketones versus epoxides. The polarity of solvent strongly influences the reaction rate and the nature of oxidation products. We suggest that L Cl functions via the formation of iron-hydroperoxo-species and the dominant mechanistic path is a radical one.

References

  1. K. Furuhashi, “Biological routes to optically active epoxides,” in Chirality in Industry, A. N. Collins, G. N. Sheldrake, and J. Crosby, Eds., pp. 167–186, John Wiley & Sons, London, UK, 1992.
  2. U. Sundermeier, C. Döbler, and M. Beller, “Recent developments in the osmium-catalyzed dihydroxylation of olefins,” in Modern Oxidation Methods, J. E. Bäckvall, Ed., p. 1, Wiley-VCH, Weinheim, Germany, 2004.
  3. M. Costas, M. P. Mehn, M. P. Jensen, and L. Que Jr., “Dioxygen activation at mononuclear nonheme iron active sites: enzymes, models, and intermediates,” Chemical Reviews, vol. 104, no. 2, pp. 939–986, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. R. Mas-Ballesté, M. Costas, T. Van Den Berg, and L. Que Jr., “Ligand topology effects on olefin oxidations by bio-inspired [FeII(N2Py2)] catalysts,” Chemistry—A European Journal, vol. 12, no. 28, pp. 7489–7500, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. K. Shikama, “The molecular mechanism of autoxidation for myoglobin and hemoglobin: a venerable puzzle,” Chemical Reviews, vol. 98, no. 4, pp. 1357–1373, 1998. View at Scopus
  6. M. Merkx, D. A. Kopp, M. H. Sazinsky, J. L. Blazyk, J. Müller, and S. J. Lippard, “Dioxygen activation and methane hydroxylation by soluble methane monooxygenase: a tale of two irons and three proteins,” Angewandte Chemie International Edition, vol. 40, no. 15, pp. 2782–2807, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. S. C. Pulver, W. A. Froland, J. D. Lipscomb, and E. I. Solomon, “Ligand field circular dichroism and magnetic circular dichroism studies of component B and substrate binding to the hydroxylase component of methane monooxygenase,” Journal of the American Chemical Society, vol. 119, no. 2, pp. 387–395, 1997. View at Publisher · View at Google Scholar · View at Scopus
  8. M. D. Wolfe, J. V. Parales, D. T. Gibson, and J. D. Lipscomb, “Single turnover chemistry and regulation of O2 activation by the oxygenase component of naphthalene 1,2-dioxygenase,” Journal of Biological Chemistry, vol. 276, no. 3, pp. 1945–1953, 2001. View at Scopus
  9. A. Karlsson, J. V. Parales, R. E. Parales, D. T. Gibson, H. Eklund, and S. Ramaswamy, “Crystal structure of naphthalene dioxygenase: side-on binding of dioxygen to iron,” Science, vol. 299, no. 5609, pp. 1039–1042, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. R. H. Holm, P. Kennepohl, and E. I. Solomon, “Structural and functional aspects of metal sites in biology,” Chemical Reviews, vol. 96, no. 7, pp. 2239–2314, 1996. View at Scopus
  11. V. K. Sivasubramanian, M. Ganesan, S. Rajagopal, and R. Ramaraj, “Iron(III)-salen complexes as enzyme models: mechanistic study of oxo(salen)iron complexes oxygenation of organic sulfides,” Journal of Organic Chemistry, vol. 67, no. 5, pp. 1506–1514, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. X. Shan and L. Que Jr., “High-valent nonheme iron-oxo species in biomimetic oxidations,” Journal of Inorganic Biochemistry, vol. 100, no. 4, pp. 421–433, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. K. C. Gupta, A. Kumar Sutar, and C.-C. Lin, “Polymer-supported Schiff base complexes in oxidation reactions,” Coordination Chemistry Reviews, vol. 253, no. 13-14, pp. 1926–1946, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. R. B. Bedford, D. W. Bruce, R. M. Frost, J. W. Goodby, and M. Hird, “Iron(III) salen-type catalysts for the cross-coupling of aryl Grignards with alkyl halides bearing β-hydrogens,” Chemical Communications, no. 24, pp. 2822–2823, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. K. P. Bryliakov and E. P. Talsi, “Evidence for the formation of an iodosylbenzene(salen)iron active intermediate in a (salen)iron(III)-catalyzed asymmetric sulfide oxidation,” Angewandte Chemie International Edition, vol. 43, no. 39, pp. 5228–5230, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. L. Que Jr. and W. B. Tolman, “Recurring structural motifs in bioinorganic chemistry,” in Bio-Coordination Chemistry, J. A. McCleverty and T. J. Meyer, Eds., vol. 8 of Comprehensive Coordination Chemistry II, Elsevier, Oxford, UK, 2004.
  17. E. Y. Tshuva and S. J. Lippard, “Synthetic models for non-heme carboxylate-bridged diiron metalloproteins: strategies and tactics,” Chemical Reviews, vol. 104, no. 2, pp. 987–1012, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. A. L. Feig and S. J. Lippard, “Reactions of non-heme iron(II) centers with dioxygen in biology and chemistry,” Chemical Reviews, vol. 94, no. 3, pp. 759–805, 1994. View at Scopus
  19. C. He and Y. Mishina, “Modeling non-heme iron proteins,” Current Opinion in Chemical Biology, vol. 8, no. 2, pp. 201–208, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. J.-U. Rohde, M. R. Bukowski, and L. Que Jr., “Functional models for mononuclear nonheme iron enzymes,” Current Opinion in Chemical Biology, vol. 7, no. 6, pp. 674–682, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Chen and L. Que Jr., “Evidence for the participation of a high-valent iron-oxo species in stereospecific alkane hydroxylation by a non-heme iron catalyst,” Chemical Communications, no. 15, pp. 1375–1376, 1999. View at Scopus
  22. M. Costas, A. K. Tipton, K. Chen, D.-H. Jo, and L. Que Jr., “Modeling rieske dioxygenases: the first example of iron-catalyzed asymmetric cis-dihydroxylation of olefins,” Journal of the American Chemical Society, vol. 123, no. 27, pp. 6722–6723, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. K. Chen, M. Costas, J. Kim, A. K. Tipton, and L. Que Jr., “Olefin cis-dihydroxylation versus epoxidation by non-heme iron catalysts: two faces of an FeIII-OOH coin,” Journal of the American Chemical Society, vol. 124, no. 12, pp. 3026–3035, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. P. D. Oldenburg, A. A. Shteinman, and L. Que Jr., “Iron-catalyzed olefin cis-dihydroxylation using a bio-inspired N,N, O-ligand,” Journal of the American Chemical Society, vol. 127, no. 45, pp. 15672–15673, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. C. P. Horwitz, D. R. Fooksman, L. D. Vuocolo, S. W. Gordon-Wylie, N. J. Cox, and J. T. Collins, “Ligand design approach for securing robust oxidation catalysts,” Journal of the American Chemical Society, vol. 120, pp. 4867–4868, 1998.
  26. T. J. Collins, “TAML oxidant activators: a new approach to the activation of hydrogen peroxide for environmentally significant problems,” Accounts of Chemical Research, vol. 35, no. 9, pp. 782–790, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. J. M. Rowland, M. Olmstead, and P. K. Mascharak, “Syntheses, structures, and reactivity of low spin iron(III) complexes containing a single carboxamido nitrogen in a [FeN5L] chromophore,” Inorganic Chemistry, vol. 40, no. 12, pp. 2810–2817, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Klopstra, G. Roelfes, R. Hage, R. M. Kellogg, and B. L. Feringa, “Non-heme iron complexes for stereoselective oxidation: tuning of the selectivity in dihydroxylation using different solvents,” European Journal of Inorganic Chemistry, vol. 4, pp. 846–856, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. F. G. Gelalcha, G. Anilkumar, M. K. Tse, A. Brückner, and M. Beller, “Biomimetic iron-catalyzed asymmetric epoxidation of aromatic alkenes by using hydrogen peroxide,” Chemistry—A European Journal, vol. 14, no. 25, pp. 7687–7698, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. L. Que Jr. and R. Y. N. Ho, “Dioxygen activation by enzymes with mononuclear non-heme iron active sites,” Chemical Reviews, vol. 96, no. 7, pp. 2607–2624, 1996. View at Scopus
  31. M. Costas, K. Chen, and L. Que Jr., “Biomimetic nonheme iron catalysts for alkane hydroxylation,” Coordination Chemistry Reviews, vol. 200–202, pp. 517–544, 2000. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Lubben, A. Meetsma, E. C. Wilkinson, B. Feringa, and L. Que Jr., “Nonheme iron centers in oxygen activation: characterization of an iron(III) hydroperoxide intermediate,” Angewandte Chemie International Edition in English, vol. 34, no. 13-14, pp. 1512–1514, 1995. View at Scopus
  33. I. Bernal, I. M. Jensen, K. B. Jensen, C. J. McKenzie, H. Toftlund, and J. Tuchagues, “Iron(II) complexes of polydentate aminopyridyl ligands and an exchangeable sixth ligand; Reactions with peroxides,” Journal of the Chemical Society, Dalton Transactions, no. 22, pp. 3667–3675, 1995. View at Publisher · View at Google Scholar · View at Scopus
  34. J. Kim, E. Larka, E. C. Wilkinson, and L. Que Jr., “An alkylperoxoiron(III) intermediate and its role in the oxidation of aliphatic C-H Bonds,” Angewandte Chemie (International Edition in English), vol. 34, no. 18, pp. 2048–2051, 1995. View at Scopus
  35. B. J. Wallar and J. D. Lipscomb, “Dioxygen activation by enzymes containing binuclear non-heme iron clusters,” Chemical Reviews, vol. 96, no. 7, pp. 2625–2657, 1996. View at Scopus
  36. M. Louloudi, K. Mitopoulou, E. Evaggelou, Y. Deligiannakis, and N. Hadjiliadis, “Homogeneous and heterogenized copper(II) complexes as catechol oxidation catalysts,” Journal of Molecular Catalysis A, vol. 198, no. 1-2, pp. 231–240, 2003. View at Publisher · View at Google Scholar · View at Scopus
  37. C. Vartzouma, E. Evaggellou, Y. Sanakis, N. Hadjiliadis, and M. Louloudi, “Alkene epoxidation by homogeneous and heterogenised manganese(II) catalysts with hydrogen peroxide,” Journal of Molecular Catalysis A, vol. 263, no. 1-2, pp. 77–85, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. G. Bilis, K. C. Christoforidis, Y. Deligiannakis, and M. Louloudi, “Hydrocarbon oxidation by homogeneous and heterogeneous non-heme iron (III) catalysts with H2O2,” Catalysis Today. In press.
  39. G. Grigoropoulou, K. C. Christoforidis, M. Louloudi, and Y. Deligiannakis, “Structure-catalytic function relationship of SiO2-immobilized mononuclear Cu complexes: an EPR study,” Langmuir, vol. 23, no. 20, pp. 10407–10418, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  40. D. P. E. Dickson and F. J. Berry, Mossbauer Spectroscopy, Cambridge University Press, Cambridge, UK, 1996.
  41. J. Peisach, W. E. Blumberg, S. Ogawa, E. A. Rachmilewitz, and R. Oltzik, “The effects of protein conformation on the heme symmetry in high spin ferric heme proteins as studied by electron paramagnetic resonance,” Journal of Biological Chemistry, vol. 246, no. 10, pp. 3342–3355, 1971. View at Scopus
  42. A. Dhakshinamoorthy and K. Pitchumani, “Clay-anchored non-heme iron-salen complex catalyzed cleavage of C=C bond in aqueous medium,” Tetrahedron, vol. 62, no. 42, pp. 9911–9918, 2006. View at Publisher · View at Google Scholar · View at Scopus
  43. G. C. Silva, G. L. Parrilha, N. M. F. Carvalho, V. Drago, C. Fernandes, A. Horn Jr., and O. A. C. Antunes, “A bio-inspired Fe(III) complex and its use in the cyclohexane oxidation,” Catalysis Today, vol. 133–135, no. 1–4, pp. 684–688, 2008. View at Publisher · View at Google Scholar · View at Scopus
  44. F. Farzaneh, M. Poorkhosravani, and M. Ghandi, “Utilization of immobilized biomimetic iron complexes within nanoreactors of Al-MCM-41 as cyclohexane oxidation catalyst,” Journal of Molecular Catalysis A, vol. 308, no. 1-2, pp. 108–113, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. S. Tanase and E. Bouwman, “Selective conversion of hydrocarbons with H2O2 using biomimetic non-heme iron and manganese oxidation catalysts,” Advances in Inorganic Chemistry, vol. 58, pp. 29–75, 2006. View at Publisher · View at Google Scholar · View at Scopus
  46. G. Roelfes, M. Lubben, R. Hage, L. Que Jr., and B. L. Feringa, “Catalytic oxidation with a non-heme iron complex that generates a low-spin FeIIIOOH intermediate,” Chemistry—A European Journal, vol. 6, no. 12, pp. 2152–2159, 2000. View at Scopus
  47. P. A. MacFaul, K. U. Ingold, D. D. M. Wayner, and L. Que Jr., “A putative monooxygenase mimic which functions via well-disguised free radical chemistry,” Journal of the American Chemical Society, vol. 119, no. 44, pp. 10594–10598, 1997. View at Publisher · View at Google Scholar · View at Scopus
  48. F. Gozzo, “Radical and non-radical chemistry of the Fenton-like systems in the presence of organic substrates,” Journal of Molecular Catalysis A, vol. 171, no. 1-2, pp. 1–22, 2001. View at Publisher · View at Google Scholar · View at Scopus