Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands

<table>Reaction scheme for the synthesis of the [Ru(<svg height="20.137501" id="M13" style="vertical-align:-3.56265pt" version="1.1" viewbox="0 0 14.85 20.137501" width="14.85" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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q-8 0 -28.5 -14t-38.5 -32l-17 22q41 43 85 71t66 28q23 0 23 -39q0 -19 -10 -64l-24 -103h2q77 101 201 182q37 24 74 24q31 0 31 -47z" id="x1D702"></path></g>
<g transform="matrix(.012,-0,0,-.012,8.462,7.475)"><path d="M153 550l-26 -186q79 31 111 31q90 0 141.5 -51t51.5 -119q0 -93 -89 -166q-85 -69 -173 -71q-32 0 -61.5 11.5t-41.5 23.5q-18 17 -17 34q2 16 22 33q14 9 26 -1q61 -50 124 -50q60 0 93 43.5t33 104.5q0 69 -41.5 110t-121.5 41q-53 0 -102 -20l38 305h286l6 -8
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</svg>-C<sub>5</sub>H<sub>5</sub>)(PPh<sub>3</sub>)<sub>2</sub>(L)][PF6] complexes <b>1</b>–<b>4 </b>and the structures of the ligands L.</table>

Bioinorganic Chemistry and Applications

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Scheme 1

Scheme 1: Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands 