Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands

Table 3

Percentage of HL-60 cells in each state after treatment with metal complexes at IC₅₀ concentration for 24 hours of incubation.

Treatment (IC50 24 hours 𝜇M)	% vital cells (R1)	% apoptotic cells (R2)	% dead cells (R3)	% damaged cells (R4)
Control	91.1	4.8	3.9	0.2
CDDP	55.0	40.7	3.6	0.7
[Ru(𝜂^5-C5H5)(PPh3)2TzH]^+1	74.7	19.9	5.0	0.4
[Ru(𝜂^5-C5H5)(PPh3)2ImH]^+2	62.6	29.8	7.3	0.3
[Ru(𝜂^5-C5H5)(PPh3)2Bdt]^+3	60.0	20.8	13.3	5.9
[Ru(𝜂^5-C5H5)(PPh3)2Tvt]^+4	51.4	18.1	21.0	9.5