Alkene Cleavage Catalysed by Heme and Nonheme Enzymes: Reaction Mechanisms and Biocatalytic Applications

Scheme 6

C=C double bond cleavage catalysed by tryptophan 2,3-dioxygenase (TDO). Historical perspective of the proposed reaction mechanisms: (a) C3-attack and Criegee rearrangement; (b) C3-attack and formation of dioxetane intermediate; (c) C2-attack via direct radical addition (current accepted mechanism).