Sensitive Marker of the Cisplatin-DNA Interaction: X-Ray Photoelectron Spectroscopy of CL
Figure 3
High-resolution XPS spectra of C 1s, N 1s, O 1s, and P 2p regions for pure oligos and cisplatin-oligo complexes at a ratio of 10 with the same amount of oligos in the films. The incubation time for the cisplatin-oligo complex is 4 hr. The peaks (solid curve) were deconvoluted into specific components of the oligo (dashed line) including (a) C 1s, urea (peak 1), amide (2), C–N/C–O–C/C–OH/N=C–C (3), and hydrocarbon (4); (b) N 1s, amino (1) and imino (2); (c) O 1s, C–OH (1), C=O/N=O (2), and phosphate group (3); (d) P 2p, the phosphate group. Note that the spectra in each figure are on the same scale, but offset for clarity.
