Research Article

DNA-Platinum Thin Films for Use in Chemoradiation Therapy Studies

Figure 5

Mobility of cisplatin-DNA molecules in agarose gel. (a) Migration of the different configurations of cisplatin-DNA molecules separated by electrophoresis. Lane 1 is for a DNA sample and lanes 2–5 are for cisplatin-DNA samples with the number of bound cisplatin molecules per nucleotide, , of 0.0057, 0.008, 0.0091, and 0.0219, respectively. (b) Normalized mobility of the nicked circular, supercoiled, and cancatemeric forms of Pt-DNA samples at different in gel electrophoresis.
923914.fig.005a
(a)
923914.fig.005b
(b)