Research Article
Synthesis, Characterization, and Interaction with Biomolecules of Platinum(II) Complexes with Shikimic Acid-Based Ligands
Scheme 1
Synthesis route for the shikimic acid derivate ligands and Pt(II) complexes (, 3, 4, 5, 6): (i) CbzCl, NaHCO3, H2O; (ii) MsCl/py/20°C, excess NH2(CH2)2NH2; (iii) (t-BuO)2CO, CH2Cl2; (iv) HCO2NH4/Pd/C; (v) Shikimic acid, DCC, HOBt; (vi) conc. HCl/MeOH/CH2Cl2; (vii) Na2CO3, K2PtCl4.