Synthesis, Characterization, and Interaction with Biomolecules of Platinum(II) Complexes with Shikimic Acid-Based Ligands

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left">Peak</td><td align="center"><i>δ</i> (ppm)</td><td align="center">Assignment</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left">H8</td><td align="center">8.11</td><td align="center">H8, free 5′-GMP</td></tr><tr><td align="left">H1′</td><td align="center">5.83</td><td align="center">H1′, ribose in free 5′-GMP</td></tr><tr><td align="left">HA</td><td align="center">6.36</td><td align="center">HA, in free Pt(L4)Cl<sub>2</sub></td></tr><tr><td align="left">H8<sub>A</sub></td><td align="center">8.65</td><td align="center">H8, mono-GMP adduct</td></tr><tr><td align="left"><span style="width: 30.15px;"><svg height="21.7875" id="M268" style="vertical-align:-3.27605pt" version="1.1" viewbox="0 0 30.15 21.7875" width="30.15" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg></span></td><td align="center">8.49</td><td align="center">H8, bis-GMP adduct</td></tr><tr><td align="left">H1′′</td><td align="center">5.78</td><td align="center">H1′, ribose in GMP adduct</td></tr><tr><td align="left">HA′</td><td align="center">6.31</td><td align="center">HA, mono-GMP adduct</td></tr><tr><td align="left">HA′′</td><td align="center">6.27</td><td align="center">HA, bis-GMP adduct</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Assignments of the selected peaks in <sup>1</sup>H NMR spectra for reaction of complex PtL<sup>b</sup>Cl<sub>2</sub> with 5′-GMP.

Bioinorganic Chemistry and Applications

tab4

Table 4

Table 4: Synthesis, Characterization, and Interaction with Biomolecules of Platinum(II) Complexes with Shikimic Acid-Based Ligands 