Evaluation of DNA Binding, Cleavage, and Cytotoxic Activity of Cu(II), Co(II), and Ni(II) Schiff Base Complexes of 1-Phenylindoline-2,3-dione with Isonicotinohydrazide

Figure 8

Cleavage of super coiled pUC19 (10 𝜇M) by the Cu(II), Co(II), and Ni(II) complexes in the presence of triacetate EDTA (TEA) buffer at 37°C. Upper line: Form I and lower line: Form II; Lane 1: DNA-control; Lane 2: L–Cu; Lane 3: L–Co; Lane 4: L–Ni.