Synthesis, Characterization, and Anticancer Activity of New Metal Complexes Derived from 2-Hydroxy-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide

Table 6

Cytotoxic activity (IC₅₀) of the ligand and some metal complexes against human liver HepG2 cancer.

Number	Compound	IC50 (M)
Ligand	H2L, (1)	107 ± 5.2
(2)	[(HL)Cu(OAc)(H2O)2]·H2O	6.49 ± 1.7
(3)	[(HL)Cu2(OAc)3(H2O)5]	2.67 ± 1.2
(4)	[(H2L)2Cu(OAc)2]·3H2O	2.24 ± 1.2
(9)	[(HL)Co(OAc)(H2O)2]·3H2O	36.80 ± 4.0
Standard	Sorafenib (Nexavar)	11.8 ± 3.2