Research Article
The Strange Case: The Unsymmetric Cisplatin-Based Pt(IV) Prodrug [Pt(CH3COO)Cl2(NH3)2(OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier-Mediated Cellular Uptake
Table 2
Antiproliferative data (IC50, μM) for Complexes 1–3 obtained after 72 h of treatment. Data in brackets represent the resistance factor, RF = IC50 A2780cisR (cisplatin-resistant)/IC50 A2780 (wild-type), rounded to the nearest unity. Data are the mean ± standard deviation (sd) of at least three replicates.
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