New Organotin (IV) Compounds Derived from Dehydroacetic Acid and Thiosemicarbazides: Synthesis, Rational Design, Cytotoxic Evaluation, and Molecular Docking Simulation

<div>Diorganotin complexes induced morphological changes in the MDA-MB-231 breast cancer cell line. Giemsa stain of cells incubated with different organotin (IV) complexes concentrations for 48 h. Cell size reduction, rounding and pyknotic nuclei (black arrows), cytoplasm vacuolization (<b>3e</b>, box), chromatin condensation (<b>3d</b>, box), apoptotic bodies (star), cell lysis and necrosis (+). Bar: 20 <i>µ</i>m (20x).</div>

Bioinorganic Chemistry and Applications

fig12

Figure 12

Figure 12: New Organotin (IV) Compounds Derived from Dehydroacetic Acid and Thiosemicarbazides: Synthesis, Rational Design, Cytotoxic Evaluation, and Molecular Docking Simulation 

Figure 12 | New Organotin (IV) Compounds Derived from Dehydroacetic Acid and Thiosemicarbazides: Synthesis, Rational Design, Cytotoxic Evaluation, and Molecular Docking Simulation 