Review Article
Paracrine Molecules of Mesenchymal Stem Cells for Hematopoietic Stem Cell Niche
Table 1
The cytokines secreted by MSCs that regulate HSCs.
| Cytokines | Function | References |
| CXCL12 | Regulate the adhesion, expansion, migration, and homing of HSCs | [10, 11, 28ā32] | (SDF-1) | Reduce the production of inflammatory cytokines and chemokines | [33] |
| FL | Maintain HSC proliferation and self-renewal, regulate hematopoietic growth | [28] |
| IL-6, TPO | Influence HSC proliferation and differentiation | [29, 34] |
| GM-CSF | Regulate HSC engraftment | [35] |
| SCF | Maintain HSC proliferation and self-renewal | | Regulate hematopoietic growth | [28, 36] | Regulate HSC engraftment | [35] |
| VCAM1, E-selectin, collagen I, fibronectin | Regulate HSC homing and adhesion | [35, 37] |
|
|