Paracrine Molecules of Mesenchymal Stem Cells for Hematopoietic Stem Cell Niche

Table 1

The cytokines secreted by MSCs that regulate HSCs.

Cytokines	Function	References
CXCL12	Regulate the adhesion, expansion, migration, and homing of HSCs	[10, 11, 28–32]
(SDF-1)	Reduce the production of inflammatory cytokines and chemokines	[33]
FL	Maintain HSC proliferation and self-renewal, regulate hematopoietic growth	[28]
IL-6, TPO	Influence HSC proliferation and differentiation	[29, 34]
GM-CSF	Regulate HSC engraftment	[35]
SCF	Maintain HSC proliferation and self-renewal
	Regulate hematopoietic growth	[28, 36]
	Regulate HSC engraftment	[35]
VCAM1, E-selectin, collagen I, fibronectin	Regulate HSC homing and adhesion	[35, 37]