|
| Study | Agents | Renal Inclusion criteria | Baseline renal characteristics | Renal outcomes |
|
| San Miguel et al. (VISTA) [31] | VMP versus MP | No renal exclusions | CrCl < 30 = 6% (B), 5% (Control)
CrCl 30–60 = 28% (B), 50% (Control)
CrCl >60 = 46 (B), 46% (control) | Reversal = GFR >60 at end from <50 at start
VMP group = 44% reversal
MP group = 34% |
|
| Chanan-Khan et al. [33] | B + variety of other agents | Dialysis dependence mandatory | All but 1 dialysis dependent,
Median sCr = 6.8 mg/dL (3.1–12.8)? before starting dialysis
No renal Bx | No clear defnof renal reversal
4 had “improved” renal function (1 pt never started dialysis, 2 came off dialysis after a CR and 1 off dialysis after a MR) |
|
| Kastritis et al. [34] | VAD (or similar), M + hdD or D alone Group B: hdD + T +/_ B | sCr >2 mg/dL mandatory at enrolment | sCr >4 mg/dL = 44%
sCr 2–4 mg/dL = 56%
24% dialysis dependent
No renal Bx | sCr <2 g/dL defined as renal reversal, 83% met this defn median TTR = 1.9 mo
80% of those previously dialysed came off dialysis |
|
| Morabito et al. [35] | V + D or V + D + other agents | No renal exclusions | CrCl 51–80 = 10.3%
CrCl 30–50 = 19.7%
CrCl <30 = 70%
12% dialysis dependent | Reversal = normalisation of CrCl, occurred in 41% with no differences across treatment subgroups
22% of those previously dialysed came off dialysis |
|
| Ludwig et al. [36] | V, V + D or V, D + A | GFR <20 mls/min mandatory at enrolment | Mean sCr 9.05 mg/ml (5.2–12)
63% dialysis dependent
No renal Bx | Median sCr fell from 9.05 to 2.1 mg/dL (0.8–2.4) |
|
| Ludwig et al. [37] | VAD | GFR <50 mls/min mandatory at enrolment | Median GFR 20.5 mls/min (3.7–49.9 mls/min)
6 renal Bx (2 showed amyloid so patients excluded) | No defined criteria for renal recovery, median GFR increased to 48.4 ml/min (6.7–135.5 mls/min), improvement in GFR correlated with tumour response |
|
| Tosi et al. [38] | T + other | sCr >130 μmol/l mandatory at enrolment | Initial sCr for all listed,
Median = 155 μmol/l
Range 131–998 μmol/l | Yes, Improvement defined as sCr <130 μmol/l, 12/15 responding pts had renal recovery |
|
| Dimopoulos et al. [39] | R + D | No renal exclusions | 24 had baseline CrCl, 50 (13–49), 2% dialysis dependent at baseline | Recovery defined as either CrCl, 50 to >60 or movement from one subgroup to another, 42% of those with renal impairment had some improvement |
|
| Dimopoulos et al. [40] | R + D versus D | sCr <2.5 mg/dL | CrCl >60 = 71%
CrCl 30–60 = 24%
CrCl <30 = 5% | Improvement defined as movement from one subgroup to a better one, 72% of those who received R+D had some improvement, data for D alone not quoted |
|
|
Dimopoulos et al. [40] | R + D | No renal exclusions | CrCl >80 = 56%
CrCl 50–80 = 23.9%
CrCl 30–50 = 12.6%
CrCl <30 = 7.2%
3% dialysis dependent | 26.6% had some change from one renal subgroup to another, 12.5% had deterioration of renal function |
|
