Future Perspectives: Therapeutic Targeting of Notch Signalling May Become a Strategy in Patients Receiving Stem Cell Transplantation for Hematologic Malignancies

Table 1

Notch ligand-receptor interaction: a summary of possible interactions involved in normal hematopoiesis, T cell development, and regulation of the peripheral T cell system.

SIGNAL-INITIATING CELL		SIGNAL-RECEIVING CELL
Cell type	Ligand	Cell type	Receptor	References
Bone marrow stromal cells		Bone marrow stem cells
Osteoblasts (endosteal niche)	JAG1	Sca-1^+, c-kit^+, Lin^-	Notch1	[13]
	JAG1, JAG2	Sca-1^+, c-kit^+, CD117^+	Notch1, Notch2	[52]
Endothelial cells (vascular niche)	JAG1, JAG2, DLL4, DLL1	Sca-1^+, c-kit^+, Lin^-	Notch1, Notch2	[24]
Thymic epithelial cells (TECs)		T cell progenitors
TECs	DLL4	Thymocytes	Notch1	[1, 50]
Antigen-presenting cells		Peripheral T cells
APC	DLL1	Tc	Notch1, Notch2	[1]
DC	DLL1, DLL4	Th1	Notch3	[1, 8, 53]
DC	JAG1, JAG2	Th2	Notch1, Notch2	[1, 8, 53]
APC	DLL1, DLL4	Th17	Notch	[1, 54]
pDC	DLL4	Th1 IL-10^+	Notch	[55]

Abbreviations: Delta-like (DLL); Jagged (JAG); Thymic epithelial cells (TECs); Antigen presenting cells (APC); Dendritic cells (DC); plasmacytoid DC (pDC); Cytotoxic T cells (Tc); Helper T cells (Th); Interleukin-10 (IL-10).