NOD2 Polymorphisms and Their Impact on Haematopoietic Stem Cell Transplant Outcome

Figure 1

The structure of the NOD2 gene and NOD2 protein. The numbering in the black boxes indicates the exon numbers. The numbering alongside the protein diagram indicates the amino acid positioning. SNPs 8, 12, and 13 are located within exons 4, 8 and 11 respectively, and encode either amino acid substitutions (SNPs 8 and 12) or a frame-shift causing early truncation of the protein (SNP 13).