Differential Expression of Matrix Metalloproteinase-2 Expression in Disseminated Tumor Cells and Micrometastasis in Bone Marrow of Patients with Nonmetastatic and Metastatic Prostate Cancer: Theoretical Considerations and Clinical Implications—An Immunocytochemical Study

Table 5

Concordance between the expression of MMP-2 in CPCs, DTCs, and mM according to Gleason score.

Kappa: MMP-2	Gleason 4	Gleason 5 + 6	Gleason 7	Gleason 8 + 9
CPC + DTC	0.64	0.59	0.78	0.57
CPC + mM	0	0.14	0.19	0.23
DTC + mM	0	0.13	0.17	0.30

Kappa values: 0–0.2 no concordance, 0.21–0.40 low concordance, 0.41–0.60 moderate concordance, 0.61–0.8 good concordance, >0.80 excellent concordance.