Differential Expression of Matrix Metalloproteinase-2 Expression in Disseminated Tumor Cells and Micrometastasis in Bone Marrow of Patients with Nonmetastatic and Metastatic Prostate Cancer: Theoretical Considerations and Clinical Implications—An Immunocytochemical Study

Table 6

Expression of MMP-2 in mM and surrounding stromal cells in patients with MMP-2 expressing mM.

No. of patients	Gleason 4	Gleason 5 + 6	Gleason 7	Gleason 8 + 9
mM positive 71.4% (𝑛=132)	32.1% (9)	77.4% (82)	77.4% (22)	85% (17)
MMP-2 in mM	0%	14.6% (11)	20.8% (5)	41.1% (7)	Trend chi squared; 𝑃=0.031
MMP-2 in stromal cells	0%	0%	4.5% (1)	11.8% (2)