Hematopoietic Stem Cell Development, Niches, and Signaling Pathways

Figure 4

Hierarchy of hematopoiesis. The phenotypic cell surface marker of each population of mouse and human blood system is shown (modified from [13]). In the mouse hematopoiesis system, MPPs omit CMPs which directly give rise to MEPs unlink in the human system (dash line). CLP, common lymphoid progenitor; CMP, common myeloid progenitor; DC, dendritic cell; EP, erythrocyte progenitor; GMP, granulocyte/macrophage progenitor; GP, granulocyte progenitor; HSC, hematopoietic stem cell; MacP, macrophage progenitor; MEP, megakaryocyte/erythrocyte progenitor; MkP, megakaryocyte progenitor; NK, natural killer; Lin, lineage markers.