Influence of Bisphosphonate Treatment on Medullary Macrophages and Osteoclasts: An Experimental Study

Figure 4

Macrophages in diaphyseal bone marrow. Microphotographs of histologic sections with ED1 immunohistochemical detection and hematoxylin-counterstain. Brown cells correspond to positive cells (macrophages). (a) shows a microphotograph of a sham animal, (b) an olpadronate-treated animal and (c) and alendronate-treated one. (b) and (c) show a lower number of positive cells.

(a)

(b)

(c)