Influence of Bisphosphonate Treatment on Medullary Macrophages and Osteoclasts: An Experimental Study
Figure 5
Microphotographs of osteoclasts stained for IHC detection of ED1. Microphotograph (a) shows the distribution pattern of the marker in the cytoplasm of osteoclasts of sham group sections; the light areas indicate abundant vesicles (*). (b) and (c) show osteoclasts corresponding to olpadronate and alendronate-treated animals, respectively. The cytoplasm exhibits a homogenous distribution pattern of ED1. (d) shows an apoptotic osteoclast staining intensely positive for ED1. N: nucleus. The bar represents 50 microns.
