Th17 Mediated Alloreactivity Is Facilitated by the Pre-Transplant Microbial Burden of the Recipient

<table>Colon biopsy specimen harvested at 33 days after HSCT from patient with clinical symptoms of aGvHD. Hematoxylin and eosin (H+E) staining documented destruction of colon crypts, and immunocytochemistry illustrate CD8+ cells invading damaged crypt epithelium (H+E magnification 200x, red staining with Permanent Red, magnifications 400x).</table>

Bone Marrow Research

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Figure 2

Figure 2: Th17 Mediated Alloreactivity Is Facilitated by the Pre-Transplant Microbial Burden of the Recipient 