Bone Marrow Research / 2013 / Article / Tab 2 / Clinical Study
Day 100 Peripheral Blood Absolute Lymphocyte/Monocyte Ratio and Survival in Classical Hodgkin's Lymphoma Postautologous Peripheral Blood Hematopoietic Stem Cell Transplantation Table 2 Baseline characteristics based on Day 100 ALC/AMC.
Characteristics Day 100 ALC/AMC ≥ 1.3 (
= 99) Day 100 ALC/AMC < 1.3 (
= 32)
valueAt diagnosis Age, years, median (range) 33 (18–68) 32 (18–56) 0.8 Gender <0.008 Male 44 (44%) 23 (72%) Female 55 (56%) 9 (28%) Albumin (g/dL) 4 (2–4.6) 3.9 (2.2–4.6) <0.008 ALC × 109 /L 1.7 (0.2–2.9) 0.5 (0.2–2.7) <0.0001 Hemoglobin (g/dL) 12.6 (7.7–16.2) 11.1 (8.1–15.4) 0.07 Mediastinal disease <0.004 ≥10 cm 10 (10%) 4 (34%) <10 cm 89 (90%) 21 (66%) Stage 0.9 I 5 (5%) 1 (3%) II 42 (43%) 14 (44%) III 26 (26%) 9 (28%) IV 26 (26%) 8 (25%) Stage 0.9 Limited 46 (47%) 15 (47%) Advanced 52 (53%) 17 (53%) WBC × 109 /L 8.0 (1.4–22.2) 12.1 (2.3–20.1) <0.0003 IPS risk factors Age, years 0.9 ≤45 82 (83%) 27 (84%) >45 17 (17%) 5 (16%) Albumin (g/dL) (
= 127) <0.002 ≥4 68 (71%) 12 (39%) <4 28 (29%) 19 (61%) ALC × 109 /L <0.0001 ≥0.6 92 (93%) 14 (44%) <0.6 7 (7%) 18 (56%) Hemoglobin (g/dL) 0.06 >10.5 81 (82%) 21 (66%) ≤10.5 18 (18%) 11 (34%) Male 44 (44%) 23 (72%) <0.008 Stage 4 26 (26%) 8 (25%) 0.9 WBC × 109 /L <0.001 >15 9 (9%) 11 (34%) ≤15 90 (91%) 21 (66%) IPS score <0.01 0 26 (26%) 4 (13%) 1 33 (34%) 8 (25%) 2 21 (21%) 6 (18%) 3 10 (10%) 3 (9%) 4 6 (6%) 4 (13%) 5 3 (3%) 4 (13%) 6 0 (0%) 3 (9%) IPS index <0.009 ≥3 19 (19%) 14 (44%) <3 80 (81%) 18 (56%) At transplant Infused CD34+ stem cells × 106 /kg 5.3 (2.6–15.8) 4.5 (2.1–13.2) 0.1 Pretransplant response 0.06 CR 27 (27%) 3 (9%) PR 72 (72%) 29 (91%) ALC × 109 /L 0.78 (0.1–3.67) 0.39 (0.18–3.19) <0.0001 ALC × 109 /L <0.0001 ≥0.5 80 (81%) 10 (31%) <0.5 19 (19%) 22 (69%) At day 100 post-APBHSCT Age, years 36 (18–66) 34.5 (19–58) 0.9 Hemoglobin (g/dL) 12.1 (8.5–16.7) 11.4 (7.3–14.1) 0.4 WBC × 109 /L 4.6 (2.2–9.4) 3.7 (1.5–14.3) 0.1 ANC × 109 /L 2.6 (0.8–6.9) 2.4 (1.0–10.0) 0.9 ALC × 109 /L 1.33 (0.51–4.61) 0.39 (0.15–3.94) <0.0001 AMC × 109 /L 0.43 (0.15–1.58) 0.63 (0.29–4.02) <0.0001 Plts × 109 /L 172 (121–373) 163 (177–334) 0.2
Abbreviations: ALC: absolute lymphocyte count; ANC: absolute neutrophil count; AMC: absolute monocyte count; CR: complete remission; IPS: international prognostic score; PR: partial response; Plts: platelets; and WBC: white blood cell count.