Autologous Graft versus Host Disease: An Emerging Complication in Patients with Multiple Myeloma

Table 2

Clinical summaries of MM patients who developed autoGVHD (1–8) and who did not (9–24).

Patient	Age	Sex	Race	Prior therapy	Time from MM diagnosis to collection (months)	Mobilization	Time from txp to autoGVHD diagnosis (days)	Disease course
1	66	M	CA	B, A, and D	2	BDTPACE + G	33	autoGVHD between ttxp, WR, died of sepsis 1 month after 2nd txp
2	62	F	CA	None	5	DTPACE + G	35	autoGVHD after ttxp and WR, died of pneumonia 6 months later
3	56	M	H	T, D, XRT, and B	9	DTPACE + pegG/DA	28	txp, WR, and autoGVHD after 2nd txp 5 years later, near remission, died in home state 3 months later
4	63	F	CA	None	3	MBDTPACE + G	32	autoGVHD after ttxp and CR
5	66	M	CA	B, A, and D	12	MBDTPACE + G	45	autoGVHD after ttxp and CR, died of PCP pneumonia 5 months later
6	60	M	CA	B, A, D, XRT, and L	4	BDTPACE + G	15	autoGVHD after 4 of 5 txp and WR, died in home state the following year
7	51	F	CA	None	2	BDTPACE + G	14	autoGVHD after ttxp and WR, died in home state 11 months later
8	56	M	CA	B, D	1	MBDTPACE + G	31	autoGVHD after ttxp and CR
9	61	F	CA	Z	40	MBDTPACE + G	NA	txp and WR, died of pneumonia 1 month later
10	56	F	CA	D, T, B, M, P, A, C, E, L, CAR, CT, M, HBO, and txp	42	BDTPACE + PL + G	NA	WR, died of progressive disease
11	64	F	CA	D, T, M, 2 txp, L, B, A, C, E, G, PL, P, and Z	62	BDTPACE + PL + G	NA	txp and WR
12	63	M	CA	None	2	MBDTPACE + G	NA	ttxp and WR, died of multiorgan failure 25 months later
13	66	F	CA	B and A	27	BDTPACE + G	NA	txp and WR, died of RSV pneumonia the same month
14	54	F	CA	B, C, D, G, M, and; 2 txp	13	BDTPACE + PL + G	NA	CR and relapse, died of sepsis
15	68	M	CA	None	1	MBDTPACE + G	NA	ttxp and CR
16	59	M	CA	B, A, D, M, 2 txp, T, and L	108	MBDTPACE + G	NA	txp and WR, died of sepsis 45 months later
17	42	F	CA	B and D	2	G	NA	ttxp, status not known
18	66	F	CA	XRT	2	BDTPACE + G	NA	ttxp and WR, died of pneumonia 1 month later
19	52	F	AA	D	2	MBDTPACE + G	NA	ttxp and CR
20	66	M	CA	None	2	BDTPACE + G	NA	ttxp and CR
21	66	F	CA	B, A, D, C, E, P, PL, T, and PA	28	BDTPACE + G	NA	txp and WR
22	71	M	CA	None	2	BDTPACE + G	NA	txp and CR
23	69	F	CA	None	1	DTPACE + G	NA	ttxp and WR, died of pneumonia 1 month later
24	70	M	CA	B and D	12	G	NA	WR

A: adriamycin; AA: African American; B: bortezomib; C: cyclophosphamide; CA: Caucasian; CAR: carmustine; CR: complete remission; CT: cytarabine; D: dexamethasone; DA: darbepoetin alfa; E: etoposide; G: granulocyte-colony stimulating factor; H: Hispanic; HBO: hyperbaric oxygen; L: lenalidomide; M: melphalan; NA: not applicable; P: cisplatin; PA: pamidronate; PL: plerixafor; T: thalidomide; txp: single autologous stem cell transplant; ttxp: tandem autologous stem cell transplants (within 12 months); WR: without remission; XRT: local radiation therapy; Z: zoledronic acid.