Clinical Study

Comparing Two Types of Rabbit ATG prior to Reduced Intensity Conditioning Allogeneic Hematopoietic SCT for Hematologic Malignancies

Table 1

Patients, conditioning, and graft characteristics.

Patients, conditioning, and graft characteristicsATG-FThymoglobulin

Age at transplant, median (range, years)59 (40–69)51 (22–68)0.49
Number of men, (%)8 (53)9 (60)0.72
Group diagnosis, (%)
 AML6 (40)6 (40)1.00
 MDS2 (13)00.46
 CMML03 (20)0.23
 MF1 (7)01.00
 NHL/HD5 (33)4 (27)0.69
 MM 1 (7)1 (7)1.00
 Undifferentiated AL 01 (7)1.00
Complete remission at transplant, (%)15 (100)13 (87)0.48
CMV serostatus donor/recipient, (%)
 Positive recipient 11 (73)12 (80)0.67
 Positive donor 7 (47)8 (53)0.72
Reason for RIC, (%)
 Prior autologous SCT8 (53)8 (53)1.00
 Age4 (27)4 (27)1.00
 Other 3 (20)3 (20)1.00
Chemotherapy agents, (%)
 Fludarabine-busulfan 13 (87)12 (80)0.67
 Fludarabine-melphalan2 (13)3 (20)1.00
Related donor, (%)4 (27)5 (33)0.69
 HLA-identical4 (27)5 (33)0.69
Unrelated donor, (%)11 (73)10 (67)0.69
 0 mismatch8 (53)6 (40)0.46
 ≥1 mismatch3 (20)4 (27)0.67
Men donor, (%)9 (60)13 (87)0.10
Sex mismatch in GvHD sense, (%)4 (27)1 (7)0.33
Partial T cell depletion, (%)7 (47)9 (60)0.46
T cell dose, median (range,  CD3/kg)5 (0.35–130)5 (0.35–100)0.78
Blood group incompatibility, (%)
 Major4 (27)4 (27)1.00
 Minor4 (27)5 (33)0.91
Posttransplant immunosuppression, (%) 15 (100)15 (100)1.00