BET Inhibition Suppresses S100A8 and S100A9 Expression in Acute Myeloid Leukemia Cells and Synergises with Daunorubicin in Causing Cell Death

<div><b><i>Expression of S100A8 and S100A9 mRNA in AML cell lines</i></b>. qRT-PCR was used to analyse the expression of S100A8 and S100A9 mRNA in cell lines (a) and mononuclear cells from patient and healthy donors (b). Results were calculated using the ΔΔct method and expressed relative to the housekeeping gene GAPDH. Note that in patient samples the levels of both<i> S100A8</i> and<i> S100A9</i> mRNA are exceedingly high compared to GAPDH.</div>

Bone Marrow Research

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Figure 2: BET Inhibition Suppresses S100A8 and S100A9 Expression in Acute Myeloid Leukemia Cells and Synergises with Daunorubicin in Causing Cell Death 

Figure 2 | BET Inhibition Suppresses S100A8 and S100A9 Expression in Acute Myeloid Leukemia Cells and Synergises with Daunorubicin in Causing Cell Death 