BET Inhibition Suppresses S100A8 and S100A9 Expression in Acute Myeloid Leukemia Cells and Synergises with Daunorubicin in Causing Cell Death

<div>Regulation of S100A8 and S100A9 mRNA expression by BET-bromodomain inhibition. qRT-PCR was used to show that regulation of S100A8 and S100A9 mRNA by JQ1 in AML cell lines (a) and primary mononuclear cells (b). OCI-AML3 cells were used to show the effect of JQ1 was (c) dose-dependent, (d) time-dependent, and (e) reversible. 0.5μM JQ1 was used for time course and reversibility experiments. Results are expressed relative to GAPDH (mean ± SEM, n=3).</div>

Bone Marrow Research

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Figure 3: BET Inhibition Suppresses S100A8 and S100A9 Expression in Acute Myeloid Leukemia Cells and Synergises with Daunorubicin in Causing Cell Death 

Figure 3 | BET Inhibition Suppresses S100A8 and S100A9 Expression in Acute Myeloid Leukemia Cells and Synergises with Daunorubicin in Causing Cell Death 