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Journal of Biomedicine and Biotechnology
Volume 2 (2002), Issue 2, Pages 61-65
http://dx.doi.org/10.1155/S1110724302201035
Review article

Ku and the Stability of the Genome

Strahlenbiologisches Institut der Universität München, Schiller Straße 42, München 80336, Germany

Received 1 November 2001; Revised 26 November 2001; Accepted 11 December 2001

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ku proteins are associated with a variety of cellular processes such as repair of DNA-double-strand breaks, telomere maintenance and retrotransposition. In recent years, we have learned a lot about their cellular and molecular functions and it has turned out that Ku-dependent processes affect the stability of the genome, both positively and negatively, in several ways. This article gives an overview on the role of Ku in determining the shape of the genome.