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Journal of Biomedicine and Biotechnology
Volume 2 (2002), Issue 3, Pages 120-123
http://dx.doi.org/10.1155/S1110724302203010
Review article

Alzheimer Disease and Oxidative Stress

Institute of Pathology, Case Western Reserve University, Cleveland 44106, OH, USA

Received 11 February 2002; Accepted 18 March 2002

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Research in Alzheimer disease has recently demonstrated compelling evidence on the importance of oxidative processes in its pathogenesis. Cellular changes show that oxidative stress is an event that precedes the appearance of the hallmark pathologies of the disease, neurofibrillary tangles, and senile plaques. While it is still unclear what the initial source of the oxidative stress is in Alzheimer disease, it is likely that the process is highly dependent on redox-active transition metals such as iron and copper. Further investigation into the role that oxidative stress mechanisms seem to play in the pathogenesis of Alzheimer disease may lead to novel clinical interventions.