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Journal of Biomedicine and Biotechnology
Volume 2 (2002), Issue 2, Pages 46-54
http://dx.doi.org/10.1155/S1110724302201011
Review article

Werner Syndrome

Department of Pathology, Box 357470, HSB K-543, University of Washington, Seattle 98195-7470, WA, USA

Received 19 December 2001; Accepted 4 January 2002

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Werner syndrome is a premature aging disease caused by the mutation in the WRN gene. The cloning and characterization of the WRN gene and its product allows investigators to study the disease and the human aging process at molecular level. This review summarizes the recent progresses on various aspects of the WRN research including functional analysis of the protein, interactive cloning, complexes formation, mouse models, and SNPs (single nucleotide polymorphisms). These in depth investigations have greatly advanced our understanding of the disease and elucidated future research direction for Werner syndrome and the human aging process.