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Journal of Biomedicine and Biotechnology
Volume 2003 (2003), Issue 1, Pages 25-34
http://dx.doi.org/10.1155/S1110724303209013
Review article

Current and Future Gene Therapy for Malignant Gliomas

1Department of Neurosurgery, Mount Sinai School of Medicine, New York, NY 10029, USA
2Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA

Received 4 June 2002; Accepted 19 July 2002

Copyright © 2003 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Malignant gliomas are the most common neoplasm in the central nervous system. When treated with conventional treatments including surgery, irradiation, and chemotherapy, the average life expectancy of the most malignant type, glioblastoma multiforme is usually less than 1 year. Therefore, gene therapy is expected to be an effective and possibly curative treatment. Many gene therapeutic approaches have demonstrated efficacy in experimental animal models. However, the current clinical trials are disappointing. This review focuses on current therapeutic genes/vectors/delivery systems/targeting strategies in order to introduce updated trends and hopefully indicate prospective gene therapy for malignant gliomas.