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Journal of Biomedicine and Biotechnology
Volume 2003 (2003), Issue 3, Pages 208-211
http://dx.doi.org/10.1155/S1110724303210019
Research article

Novel HLA Class I Alleles Associated with Indian Leprosy Patients

HLA Department, Institute of Immunohaematology (ICMR), 13th Floor, KEM Hospital, Parel, Mumbai 400012, Maharastra, India

Received 19 October 2002; Revised 23 November 2002; Accepted 6 December 2002

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Convincing results on HLA Class II associations have been reported, however data on HLA class I association are limited and inconsistent from studies in Leprosy. We present here the HLA A, B, and C allele distribution by molecular high resolution PCR-SSOP technique in 32 leprosy patients compared with the 67 controls, from the same ethnic background. The significant results from the present study were a significant increase in frequency of HLA A*0206, A*1102, B*4016, B*5110, Cw*0407, and Cw*0703 was observed when compared to controls. A striking decrease in the frequency of HLA A*0101, Cw*04011, and Cw*0602 leprosy patients was observed when compared to the controls. Further haplotype A*1102-B*4006-Cw*1502 was significantly increased among the lepromatous leprosy patients when compared to the controls. It seems that HLA class I alleles play vital roles in disease association/pathogenesis with leprosy among Indians.