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Journal of Biomedicine and Biotechnology
Volume 2003 (2003), Issue 4, Pages 237-241
http://dx.doi.org/10.1155/S1110724303210020
Review article

SELDI ProteinChip® Array Technology: Protein-Based Predictive Medicine and Drug Discovery Applications

Ciphergen Biosystems, Inc, 6611 Dumbarton Circle, Fremont 94555, CA, USA

Received 24 October 2002; Accepted 5 November 2002

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Predictive medicine, utilizing the ProteinChip® Array technology, will develop through the implementation of novel biomarkers and multimarker patterns for detecting disease, determining patient prognosis, monitoring drug effects such as efficacy or toxicity, and for defining treatment options. These biomarkers may also serve as novel protein drug candidates or protein drug targets. In addition, the technology can be used for discovering small molecule drugs or for defining their mode of action utilizing protein-based assays. In this review, we describe the following applications of the ProteinChip Array technology: (1) discovery and identification of novel inhibitors of HIV-1 replication, (2) serum and tissue proteome analysis for the discovery and development of novel multimarker clinical assays for prostate, breast, ovarian, and other cancers, and (3) biomarker and drug discovery applications for neurological disorders.